of the Authority of Biological and Pre-Clinical Models - January 2016
Designation of the Authority, Tasks and General Description
The field of
animal studies constitutes a basic and essential part of the total biological
research. This research is conducted by the university’s researchers with the
assistance of the Authority of Biological and Pre-Clinical Models (“The
is a service unit constituting a basis for the biological-medical research at
the Hebrew University. The function of the Authority is to enable university researchers
to conduct high quality research related to animals, to provide animals and
related products, a place to breed and hold the animals, veterinary
consultation and supervision, various research services and a work environment for the
institution’s researchers. The authority should perform its roles allowing the
performance of researches in the most efficient and cost-effective manner,
while maintaining the animals’ welfare. The directives of the university and
the guidelines of the Animals’ Trials Act obligate both the Authority and the
researchers to act in a defined and dictated manner. Moreover, at times there
are also guidelines dictated by the sponsoring factors and regulatory
authorities overseas, requiring strict standards for maintaining animals, as a
condition for study’s conduct.
and activity fields of the Authority
The Authority’s main objective is: management,
development and ongoing operation of all animals’ facilities in the university
- the Authority constitutes a managing, organizational and professional
setting, designated to allow the university researchers to conduct animals’
research at the highest level and maintenance of the animals’ welfare, while
developing and operating research means in the maximal effectiveness and
main services provided by the Animals’ Authority include:
Breeding, purchasing and holding animals
animals during research - caring for animals of various species during
biological and medical research performed in the animal facilities of the
Hebrew University. Maintaining the animals in accordance with the requirements
of the law in Israel and international standards.
animals (special strains - mainly GEM - Genetically Modified) - breeding of GEM
rodents and additional special strains created in the Hebrew University, or
imported under cooperation with other research institutions.
animals from commercial vendors and research institutions and providing animals
to research institutions in Israel and abroad.
over the animals’ health condition (monitoring laboratory) - constant
periodical control of “sentinel” animals representing the health condition of
the animals in the cage in which they are kept.
of animals suspected as being sick.
Operating the animal facilities array in the
the animal facilities at an adequate level in accordance with the law
requirements and international standards (AAALAC, NIH) - the Hebrew University
holds an NIH authorization (since 1986) and has an AAALC accreditation of
approval (since 2009) to conduct animals research, after examination that the
University indeed meets the required ethical requirements. These approvals are
of facilities, at a high microbiological level.
of rodents from other institutions for the purpose of research cooperation through
quarantine units, and performance of rederivation through caesarean sections.
Provision of veterinary services by
veterinarians and veterinary technicians
of anesthesia and surgery services in animals of various species and operating of
surgery rooms - performance of various research activities in accordance with
the requirements of various research groups.
a pathology service array for researchers - provision of a histopathological
service to the university researchers, including preparations of sections, stains,
slides as well as professional reading of the findings and preparing summarizing
report by a pathologist.
professional responses to researches in various aspects relating to animals’
research (models, pathology).
a professional response in cases of health problems in animals or maintaining
their welfare during the conduct of a research.
Central planning and development of research
requirements with animals.
Determination of a policy on various aspects
relating to the Authority activity.
Studying the developments, initiating,
developing and introducing technological and other improvements in the animal
Professional and ethical guidance and control
over the research activity performed on laboratory animals.
of authorization courses for researchers, students and lab technicians on
working with various laboratory animals - provision of courses, seminars and
personal training in subjects related to the correct and ethical use of animals
in ethics committees - IACUCs (professional veterinary response in accordance
with law requirements).